|Vol. 2, Issue 2,
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|Metabolic neuronal derangements secondary to
- The brain is a highly aerobic tissue, with oxygen rather than any other
metabolic substrate serving as the limiting substance for energy
- As the oxygen tension within the cell decreases, there is loss of
oxidative phosphorylation and decreased generation of ATP in the
- Intracellular ATP production becomes dependent on anaerobic glycolysis
in the cytoplasm. This produces small quantities of ATP not
sufficient to maintain cellular metabolism.
Each glucose molecule produces:
- In aerobic metabolism 36-38 ATP with oxidative phosphorylation in
- In anaerobic metabolism in hypoxic conditions 2 ATP and 2 molecules
of lactic acid in the cytoplasm
- The activity of the plasma membrane energy-dependent sodium pump
(Na+ , K+ -ATPase) is reduced.
- Failure of this active transport system causes sodium to accumulate
intracellularly with diffusion of potassium out of the cell.
- The net gain of solute is accompanied by isosmotic gain of water
resulting in cellular swelling.
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