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6 December 2016, 9:00 pm
Editorial Office

FASNR Logo

The Foundation of the ASNR is pleased to announce that we will be utilizing FluidReview, a grant management software system, for the application and review of its upcoming grant awards. The FluidReview software will streamline the LOI, application and review processes. Our FluidReview website is now open for registration. Please visit http://www.asnr.fluidreview.com/ and register for a free account if you plan on submitting an application for the following grants:

LOI deadline has passed. Application deadline Monday, Jan. 18, 9:00 am CST

  • Comparative Effectiveness Research Award
  • Scholar Award in Neuroradiology Research
  • Research Scientist Award in Neuroradiology

No LOI Required. Applications must be received by 9:00 AM CST, January 31, 2017. (Budgets that exceed $100,000 require pre-approval by the Chairs of the Research Committee prior to submission.) Please submit to Rahul Bhala, Director of Economics & Health Policy at rbhala@asnr.org.

  • Alzheimer’s Imaging Research Award

Please feel free to contact Rahul Bhala, Director of Economics & Health Policy at rbhala@asnr.org with any questions or comments. We look forward to your submissions.

 

Second Round of Alzheimer’s Grant Funding

On behalf of the Foundation of the ASNR, we are delighted to announce the second round of a funding opportunity made possible by a generous donor committed to supporting imaging research in Alzheimer’s disease and dementia.

Grant submissions are due January 31, 2017 at 9:00 AM CST.

The goal of this program is to translate the novel imaging research into strategies that will increase understanding of the mechanism of Alzheimer’s disease and help stratify populations and possible treatments. All proposals must have a clear focus on Alzheimer’s disease and may also include other neurodegenerative diseases. Submissions from collaborative research that have experience across aging and neurodegenerative diseases are strongly encouraged. Novel and creative ideas are sought from investigators at any career stage.

The ASNR …

The post Foundation of ASNR Grant Announcements: Awards and Deadlines appeared first on AJNR Blog.


4 December 2016, 6:30 pm
jross

Fellows’ Journal Club

The authors evaluated multiple parameters of reduced-FOV DTI to optimize image quality. Fifteen healthy individuals underwent cervical spinal cord 3T MRI, including an anatomic 3D Multi-Echo Recombined Gradient Echo, high-resolution full-FOV DTI with a NEX of 3 and 20 diffusion gradient directions, and 5 sets of reduced-FOV DTIs differently balanced in terms of NEX/number of diffusion gradient directions. Qualitatively, reduced-FOV DTI sequences with a NEX of >5 were significantly better rated than the full-FOV DTI and the reduced-FOV DTI with low NEX (N=3) and a high number of diffusion gradient directions (D=20). Quantitatively, the best trade-off was reached by the reduced-FOV DTI with a NEX of 9 and 9 diffusion gradient directions. They conclude that the best compromise was obtained with a NEX of 9 and 9 diffusion gradient directions, which emphasizes the need for increasing the NEX at the expense of the number of diffusion gradient directions for spinal cord DTI, unlike brain imaging.

Abstract

Figure 2 from paper
Examples of MR images available for qualitative analysis. All the images came from the same subject. Cervical levels are located on 3D T2-MERGE and sagittal T2-spin echo. Fusion of FA − 3D MERGE clearly shows that f-FOV DTI and r-FOV 3N/20D are more distorted and more blurred with less anatomic precision than the other r-FOV images.

BACKGROUND AND PURPOSE

Reduced-FOV DTI is promising for exploring the cervical spinal cord, but the optimal set of parameters needs to be clarified. We hypothesized that the number of excitations should be favored over the number of diffusion gradient directions regarding the strong orientation of the cord in a single rostrocaudal axis.

MATERIALS AND METHODS

Fifteen healthy individuals underwent cervical spinal cord MR imaging at 3T, including an anatomic 3D-Multi-Echo Recombined Gradient Echo, high-resolution full-FOV DTI with a NEX of 3 and 20 diffusion gradient

The post Cervical Spinal Cord DTI Is Improved by Reduced FOV with Specific Balance between the Number of Diffusion Gradient Directions and Averages appeared first on AJNR Blog.


3 December 2016, 6:30 pm
jross

Editor’s Choice

This is a retrospective analysis of 484 patients in a prospectively collected stroke data base. The inclusion criteria were anterior circulation ischemic stroke treated with mechanical thrombectomy at a single institution between September 2010 and October 2015 with an NIHSS score of ≤8. The purpose was to assess the clinical and interventional data in patients treated with mechanical thrombectomy in case of ischemic stroke with mild-to-moderate symptoms (n = 33). Recanalization (TICI 2b–3) was achieved in 26 (78.7%) patients. Two cases of symptomatic intracranial hemorrhage occurred. Favorable (mRS 0–2) and moderate (mRS 0–3) clinical 90-day outcome was achieved in 63.6% and 90.9% of patients, respectively. The authors conclude that the clinical outcome of patients undergoing mechanical thrombectomy for acute ischemic mild stroke due to large-vessel occlusion is predominately favorable, even in a prolonged time window.

Abstract

BACKGROUND AND PURPOSE

Mechanical thrombectomy, in addition to intravenous thrombolysis, has become standard in acute ischemic stroke treatment in patients with large-vessel occlusion in the anterior circulation. However, previous randomized controlled stroke trials were not focused on patients with mild-to-moderate symptoms. Thus, there are limited data for patient selection, prediction of clinical outcome, and occurrence of complications in this patient population. The purpose of this analysis was to assess clinical and interventional data in patients treated with mechanical thrombectomy in case of ischemic stroke with mild-to-moderate symptoms.

MATERIALS AND METHODS

We performed a retrospective analysis of a prospectively collected stroke data base. Inclusion criteria were anterior circulation ischemic stroke treated with mechanical thrombectomy at our institution between September 2010 and October 2015 with an NIHSS score of ≤8.

RESULTS

Of 484 patients, we identified 33 (6.8%) with the following characteristics: median NIHSS = 5 (interquartile range, 4–7), median onset-to-groin puncture time = 320 minutes (interquartile range, 237–528 minutes). Recanalization (TICI = 2b–3)

The post Mechanical Thrombectomy in Patients with Acute Ischemic Stroke and Lower NIHSS Scores: Recanalization Rates, Periprocedural Complications, and Clinical Outcome appeared first on AJNR Blog.


30 November 2016, 5:00 pm
bookreviews

Shah G, Wesolowski J, Choi J, Friedman ER. RadCases: Head and Neck Imaging. Thieme; 2016; 224 pp; 441 ill; $59.99

Cover of Shah

RadCases: Head and Neck Imaging features a nice series of 100 cases that illustrates both relatively common and challenging head and neck abnormalities; these cases are supplemented with additional material (150 cases), which is accessible through a scratch-off code that readers can enter into the Thieme website. These extra 150 cases provide an excellent self-quiz.

The print version shows each unknown with its history and, on the overleaf, the diagnosis is stated, the images are reproduced and labeled, and a differential diagnosis is provided, along with what are called “essential facts,” other potential and associated imaging findings, and “pearls and pitfalls.” These 100 cases and the 150 online are well chosen; however, it would have been worthwhile to include additional postoperative neck scans (along with the PET scanning). It also might have been valuable to have included more cases in which the findings were not so blatant. As we all know, the major challenge is finding or identifying lesions, not necessarily giving a differential diagnosis. For the online cases, the ability to go from images, to image annotations, to differential diagnoses, to key points makes learning efficient. This book serves as a refresher that helps one sharpen diagnostic abilities in head and neck imaging.

Side note: When some minor difficulty was encountered in accessing these web-based images, Thieme was contacted directly, and its representatives were immediately responsive and helpful in their assistance. This should be reassuring to those who purchase Thieme publications that have a web link to extra material.…

The post RadCases: Head and Neck Imaging appeared first on AJNR Blog.


27 November 2016, 6:30 pm
jross

Fellows’ Journal Club

This case series presents 18 patients with primary and secondary malignant lacrimal sac and nasolacrimal duct tumors and their pattern of tumor spread. Squamous cell carcinoma was the most common histology and, in 15/18 patients tumor involved both the lacrimal sac and duct at the time of diagnosis. In 11/16 patients on CT, the nasolacrimal bony canal was smoothly expanded without erosive changes. Tumor was not observed solely within the nasolacrimal duct in any patient. Only 1 patient presented with nodal metastasis and there was no intracranial tumor extension or perineural tumor spread. The authors conclude that malignant lacrimal sac and nasolacrimal duct tumors tend to expand the nasolacrimal bony canal, rather than erode it. CT was superior to MR imaging in characterizing expansion versus erosion of the nasolacrimal bony canal.

Summary

Figure 5 from paper
A 73-year-old woman with well-differentiated SCCA of the lacrimal sac and nasolacrimal duct. A, Post-contrast-enhanced CT demonstrates an enhancing tumor within the left lacrimal sac (arrow). B, At a slightly more inferior level (bone window), note the mild expansion of the lacrimal bony canal by tumor (arrow).

The purpose of this study was to present the imaging features of primary and secondary malignant lacrimal sac and nasolacrimal duct tumors and their pattern of tumor spread in 18 patients. The most common tumor histology in our series was squamous cell carcinoma. In 15/18 patients, tumor involved both the lacrimal sac and duct at the time of diagnosis. In 11/16 patients on CT, the nasolacrimal bony canal was smoothly expanded without erosive changes. The medial canthus region (16/18) was a frequent site of direct tumor spread. Two patients had intraconal orbital spread of tumor. Tumor spread to the sinus or nasal cavity was observed in 5/13 primary tumors. Only 1 patient presented with nodal metastasis. There was

The post Imaging Features of Malignant Lacrimal Sac and Nasolacrimal Duct Tumors appeared first on AJNR Blog.


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